Yes. In Prefect 3.x the region where your short‑lived ECS task runs is determined by the ECS cluster you target. You can override that per‑deployment so some flows run in America while others stay in Singapore. Two common patterns: 1) Keep one ECS work pool, override per‑deployment - Set

job_variables

on the deployment to point at a US‑region ECS cluster (use a full cluster ARN; the ARN includes the region). - The worker can stay on your EC2 in ap-southeast-1; it will launch tasks in the US via AWS APIs as long as its IAM creds are valid in that region. Example:

from prefect import flow

@flow
def my_flow():
    ...

# Deploy this flow to run in the US region
my_flow.deploy(
    name="my-flow-us",
    work_pool_name="ecs-pool",
    job_variables={
        "cluster": "arn:aws:ecs:us-east-1:123456789012:cluster/my-us-cluster",
        "launch_type": "EC2",
        "subnet_ids": ["subnet-aaaa", "subnet-bbbb"],
        "security_group_ids": ["sg-cccccccc"],
        "assign_public_ip": False,
        # optional, small POC defaults
        "cpu": 256,
        "memory": 512
    },
)

2) Create a second work pool per region - Make an

ecs-us

pool whose base job variables default to your US cluster/subnets/SGs. - Run a second worker on the same EC2 host that polls the US pool. - This gives clear separation and per‑pool concurrency limits, at the cost of an extra worker process. Notes and prerequisites: - Ensure you have an ECS EC2 cluster with capacity in the target US region (EC2 instances joined to the cluster, correct AMI/ECS agent, subnets/SGs). - IAM: the worker’s AWS credentials must allow ECS operations in that US region/account. - Networking:

subnet_ids

and

security_group_ids

must be from the US VPC. If these flows need to reach your RDS in Singapore, cross‑region latency and SG rules may apply. - You’re using launch type EC2 (not Fargate), which is supported—keep

launch_type: "EC2"

. Docs for more detail: - ECS worker guide - Customize job variables Want me to sketch the exact

job_variables

for your US cluster if you share the region (e.g., us-east-1 vs us-west-2), cluster ARN, and VPC subnet/SG IDs?