You can schedule it with a cron expression. “First day of each month at 10:00” is: - Cron:

0 10 1 * *

- By default, Prefect uses UTC unless you specify a timezone. Two easy ways to set this up: Option A — via CLI (Prefect 3.x)

prefect deploy ./path/to/flow.py:my_flow \
  --name monthly-10am \
  --cron "0 10 1 * *" \
  --timezone "America/New_York"

- Omit

--timezone

to run at 10:00 UTC. - Run from your project root. Option B — in Python when deploying

from prefect import flow
from prefect.schedules import Cron

@flow
def my_flow():
    ...

if __name__ == "__main__":
    my_flow.deploy(
        name="monthly-10am",
        work_pool_name="my-pool",
        schedule=Cron("0 10 1 * *", timezone="America/New_York"),
    )

Docs for more details: - Schedules (concepts) - Schedule API Do you want this to run in a specific timezone? If so, which one?