Hello, does it make sense to distribute a Prefect task using Dask (e.g. predict a large dataframe with a ML model), in a Prefect Flow that already uses a remote DaskExecutor?

Not sure I understood the issue. Is your flow already using Dask with a resource manager and you are thinking whether adding Dask executor makes sense? Can you explain your use case a bit more and share your flow?

You can use Dask Dataframes with the syntax introduced here