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How do I programmatically assign `Settings` values? E.g. I want to set `PREFECT_API_URL` from inside the python script?

For now, we only support assigning `PREFECT_API_URL` from the command line. You could try to use `os.system` to run the command in your Python script

<@U03GUVCV8DS> thanks for the suggestion. Is this setting change expected to be picked up by the current interpreter? E.g. when running:
```import os
from prefect.settings import PREFECT_API_URL, get_default_settings, Settings
os.system("prefect config set PREFECT_API_URL=<http://prefect-orion.prefect/api>")
print(PREFECT_API_URL.value())
print(get_default_settings().PREFECT_API_URL)
print(Settings().PREFECT_API_URL)```
I’m seeing:
```None
None
None```
If I add `os.environ["PREFECT_API_URL"] = "foo"` the last line switches to the desired value, but when I run a `flow` it seems to still use the local/sqlite API

Ok, looks like using `context.use_profile` is almost what I wanted:
```import prefect.context 
from prefect.settings import Profile
p = Profile(
  name="default", 
  settings={
    "PREFECT_API_URL": "<http://prefect-orion.prefect/api>"
  },
)
with prefect.context.use_profile(p):
  run_my_flow()```
Now I just need a way to install this profile as the default..

wait actually you can assign a new value to a profile in a Python script

```from prefect.settings import update_current_profile
from prefect.settings import PREFECT_API_URL

update_current_profile(settings={PREFECT_API_URL: "foo"})
assert PREFECT_API_URL.value() == "foo"```

The assertion fails for me for some reason

While
```with prefect.context.use_profile(p):
    print(PREFECT_API_URL.value())```
shows the expected value

now it works, hm.. something with my environment. Let me see

Thanks, yes. It worked for me, but I have concluded my experiments with 2.0 for now, deeming it slightly too raw for my use case. In particular, <https://prefect-community.slack.com/archives/CL09KU1K7/p1659334343783899> (/me trying to get attention for that thread here)