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I'm trying to set `PREFECT_API_URL`  programmatically in my python code but I can't, is there any example regarding this?

with prefect.settings.temporary_settings would work

I want to set it globally for my python app during the runtime, does this contextmanager support that?

Then you should set it with an environment variable before entering the app

The settings are not intended to be mutated without a context

You could also mutate the environment variable _before_ importing Prefect if you really want to do it from Python